Leaders Brighton and Hove Albion take their 20-match unbeaten run to QPR on Tuesday night.
The Seagulls, who are two points clear at the top, face an R’s side which are unbeaten in three after a goalless draw at home to Burnley in Jimmy Floyd Hasselbaink’s first match in charge.
Despite being top and unbeaten, Chris Hughton’s side have drawn seven of their 10 matches away from home, whilst the Hoops have lost just once at Loftus Road.
In another big match, second-placed Middlesbrough host fifth-placed Burnley at the Riverside Stadium.
Boro are unbeaten in four after their 0-0 draw with Birmingham on Saturday, while Burnley’s draw at QPR means they’re winless in five.
Third-placed Hull will be looking to capitalise if Brighton and Middlesbrough slip up when they host managerless Reading on Wednesday.
After three games without a win, the Tigers secured a 1-0 victory over bottom side Bolton on Saturday, while Reading, who sit four points of the play offs, fell to a third successive defeat at Preston.
Fourth-placed Derby County, who are behind Hull on goal difference, will be hoping to get back to winning ways against Bristol City.
Paul Clement’s side have drawn their last two but have lost just once at home all season.
Meanwhile, Steve Cotterill’s Robins picked up a much-needed win at Huddersfield on Saturday but are still just three points above the drop,
At the bottom, Charlton host Bolton in a big game at The Valley with both teams having found the net a combined 31 times this season.
The Addicks moved out of the drop zone at the weekend after a goalless draw against Leeds on Saturday but will be confident of beating a Bolton side which has won just once all season.
Neil Lennon’s Trotters are also yet to taste victory on the road and sit five points behind their hosts, who occupy the final safety position.
Just above Bolton sit Rotherham, who make the trip to fellow strugglers Huddersfield with just three points separating the two sides.
The Millers have lost their previous two matches, whilst the Terriers have lost four of their five matches since Chris Powell left the club.
MK Dons, who occupy the first relegation spot, host play-off chasing Sheffield Wednesday.
The Dons are winless in five after their defeat to Ipswich at the weekend, while Wednesday, who sit a point off the top-six, have lost one of their last 14.
Cardiff and Brentford, two other sides in the play-off hunt, meet in South Wales.
The Bluebirds, who sit a point ahead of the Bees and a point off sixth placed Ipswich, have lost just once at home all season.
Meanwhile, the Bees are unbeaten in five and in their two matches under Dean Smith.
Ipswich currently occupy that final play-off spot and they travel to managerless Fulham.
The Cottagers are winless in six and are sliding down the table, while Mick McCarthy’s Tractor Boys have lost just one of their last eight.
Elsewhere, Preston, who have lost one of their last 10, take on a Birmingham side two points off the play-offs, while Wolves, unbeaten in five, play Leeds on Thursday.
Cardiff vs BrentfordCharlton vs Bolton
Derby vs Bristol City
Fulham vs Ipswich
Huddersfield vs Rotherham
Middlesbriugh vs Burnley
MK Dons vs Sheffield Wednesday
Preston vs Birmingham
QPR vs Brighton
Hull vs Reading (Wed)
Wolves vs Leeds (Thu)