Manchester United travel to Derby County for their fourth round FA Cup tie on Friday knowing defeat would pile even more pressure on boss Louis van Gaal.
After last week’s 1-0 defeat at home to Southampton, the Dutchman is reportedly on the brink at Old Trafford, with fans frustrated with both their team’s results and performances.
Now LvG takes his team to the Championship high-flyers admitting defeat could end his one-and-a-half year spell at the helm.
However, County, who defeated Hartlepool in the last round, hare on a five-game winless run in the league – losing three – which has seen them slip to five points adrift of the automatic promotion spots.
United, though, have won just five of their 12 away league matches and are looking to win the competition for the first time since 2004.
These two sides last met in the FA Cup fifth round in 2009; United winning 4-1 at Pride Park with goals from Cristiano Ronaldo, Nani, Darron Gibson and Danny Welbeck.
On Saturday evening, seven-time winners Liverpool take on three-time champions West Ham United in a re-run of the famous 2006 final.
The Reds defeated the Hammers on penalties at the Millennium Stadium, but only after Steven Gerrard had scored a sensational injury-time equaliser.
However, Slaven Bilic’s side have already defeated the Merseysiders twice this season, including a 3-0 win at Anfield back in August.
The East London outfit also have the advantage of an extra three days’ rest due to Liverpool’s Capital One Cup semi-final victory – on penalties – against Stoke on Tuesday.
Reigning Premier League champions face a potential banana skin as they meet MK Dons for the first time.
The Blues are unbeaten in seven matches since Guus Hiddink arrived in December and are on a high after last weekend’s 1-0 victory at Arsenal.
This competition is also close to the Dutchman’s heart after he lifted the trophy during his first spell in charge of the London in 2009.
Their hosts, who needed a replay to see off League Two Northampton in the last round, have won just six of their 14 matches at stadium:mk and are just outside the relegation zone in the Championship.
In Saturday’s early kick-off, in-form Tottenham also step into the unknown as they make the trip to take on League One strugglers Colchester.
The U’s are currently bottom of the third-tier and without a win in their last 14 league matches, but they did see off Championship side Charlton Athletic 2-1 at the Weston Homes Community Stadium in the previous round.
On the other hand, Spurs, who progressed after defeating Premier League leaders Leicester City away in their replay, are flying in the Premier League, sitting five points off top spot.
Mauricio Pochettino’s side have also lost just once on the road in the league this season and are looking to win the competition for a ninth time – but first time since 1991.
On Sunday, five-time winners Everton will be looking to avoid getting knocked out a second cup competition this week when they travel to face the lowest ranked team left in the competition, Carlisle United.
The Toffees fell to a 4-3 aggregate defeat against Manchester City in their Capital One Cup semi-final on Wednesday, so will now be aiming to keep their only hopes of silverware this term alive.
Roberto Martinez’s side, who defeated Dagenham & Redbridge in the previous round, have conceded too many goals this term (34 in 23 league matches) and have won just three of their 11 away league matches.
Despite visiting a side three leagues below them, the Merseysiders take on a side who have lost just three home matches this season, but one of those came away from Brunton Park, where the Keith Curle’s side returned to for the first time in seven weeks last time out, due to flooding caused by Storm Desmond.
Portsmouth, also of League Two and in the fourth round for the first time since reaching the final in 2010, take on Bournemouth at Fratton Park in a South-Coast derby.
When Pompey lifted the trophy back in 2008, they were thriving in the Premier League and the Cherries were relegated to League Two.
Now, with the tables fully turned, Eddie Howe’s team make the short trip expected to advance to the fifth round.
However, they’ve won just three times away from home all season and Paul Cook’s hosts have lost twice in 14 league outings in front of their own fans.
The other fourth-tier side to make it to this stage is Oxford United, who caused the biggest shock of the third round by defeating Swansea City 3-2.
Now Michael Appleton’s side take on Championship side Blackburn Rovers with the aim of reaching the last-16 for the first time since 1994.
The U’s have lost just twice at home in League Two, while Rovers are winless in seven league matches and have won just four times away from Ewood Park in all competitions this term.
Holders Arsenal, who have won the trophy the last two years, welcome Burnley to the Emirates.
The Gunners have lost just twice at home in the league all season and saw off Sunderland in the last round.
However, after getting knocked out by the Clarets’ rivals Blackburn at home in 2013, Arsene Wenger will be wary of the threat Sean Dyche’s visitors can pose, especially as they’re currently on a six-match unbeaten run in all competitions.
In one of three all Premier League ties, strugglers Aston Villa welcome Manchester City to the Midlands.
Despite their precarious position, the Villans are unbeaten in their last five games in all competitions and secured a goalless draw against the Citizens in Remi Garde’s first game in charge back in November.
However, they face a City side who have just reached the Capital One Cup final, are unbeaten in their last six league matches and have a manage in Manuel Pellegrini who is looking to add an FA Cup to the League Cup and Premier League trophies he won back in 2014.
These two sides have met twice in the competition in the last 10 years, with City winning on both occasions, including a 3-0 win on their way to lifting the trophy in 2011.
Elsewhere, Crystal Palace play Stoke at Selhurst Park, Watford make the trip to in-form Nottingham Forest, Bolton Wanderers play Leeds United in a all-Championship tie and West Brom welcome League One Peterborough to the Hawthorns after needing a last minute goal and replay to overcome Bristol City in the last round.
In the remaining ties, League One Bury host 2014 runners-up Hull City, Sheffield Wednesday travel to Shrewsbury and Walsall will be looking to knock out Championship opposition on the road for the second consecutive round when they travel to the Madejski to take on last season’s semi-finalists Reading.