Burton hold a five-point cushion at the top of League One, and they will look to extend that as they travel to a Southend side that are falling just short of the top-six on Monday night.
Albion are in decent form too having taken nine from a possible 15, and they also have a game in hand over second-placed Gillingham.
Southend are in seventh after losing their last two league matches. United are three points off of the play-offs though, and they know they need to stop the rot if they are to realise their ambition of Championship football.
More points will be dropped to the league leaders this weekend, as third-place Walsall take on fourth-placed Wigan Athletic.
The Saddlers are on 57 points, six points behind Burton, and a point better off than Athletic. Sean O’Driscoll’s men have only taken two wins from seven matches which is not the form of a side aiming for automatic promotion, but they have a game in hand over Gillingham which could be the difference.
The Latics’ draw to struggling Oldham last weekend denied them the chance to jump into second, but with 24 points taken on the road this season, they will fancy their chances ahead of their trip to the Bescot.
Meanwhile, second-placed Gillingham travel to face second-from-bottom Oldham.
The Gills have only taken two victories from their last six, with three points ensuring they keep the leaders in check. Athletic are on 26 points, five from safety. Despite this, John Sheridan’s men are unbeaten in three having taken five points, a run that has kept their chances of survival alive.
Crewe are also in the drop-zone but incredibly are without a loss in six, albeit five of those have been draws.
The Alex are just three points from Chesterfield and safety. And it is the Spirits that are Crewe’s hosts on Saturday, in what could be a crucial fixture in both sides’ seasons.
Bottom club Colchester are a massive eight points from safety, and have gone without a league win since October. They take on a Bury side who only have two wins in nine themselves, and a 6-0 thrashed at the hands of Coventry last weekend.
Barnsley’s renaissance of seven straight wins was ended last weekend with a loss to Gillingham, but they will still have one eye on the play-off positions – they are currently eight points adrift of sixth-placed Millwall.
Doncaster are the visitors to Oakwell, with Rovers lying four places and six points behind the hosts, having lost their last three matches.
Elsewhere, Bradford host Rochdale, bottom-of-the-table Colchester make the long trip north to Bury, Fleetwood welcome Scunthorpe to Highbury, Millwall will test their poor home record against Peterborough, Sheffield United face Port Vale at Bramall Lane and Blackpool travel to Swindon.
League One Fixtures (3pm)
Saturday, February 20
Barnsley vs Doncaster Rovers
Bradford City vs Rochdale
Bury vs Colchester United
Chesterfield United vs Crewe Alexandra
Fleetwood Town vs Scunthorpe United
Millwall vs Peterborough United
Oldham Athletic vs Gillingham
Sheffield United vs Port Vale
Swindon Town vs Blackpool
Walsall vs Wigan Athletic
Monday, February 22
Southend United vs Burton Albion (7:45pm)