League Two leaders Northampton will be determined to extend their unbeaten league run to a remarkable 15 games when they visit lowly Stevenage on Saturday afternoon.
The Cobblers, who are already 11 points clear of second-placed Oxford United with a game in hand, take on opponents who have lost their last four league outings on the trot and who are currently seven points above the drop zone with ten fixtures remaining.
Elsewhere; runners-up Oxford will be looking to close that gap at the summit when they travel to Barnet.
The U’s, who comfortably eased past rock-bottom Dagenham & Redbridge 4-0 on Tuesday night, have won four of their last six games, meanwhile the hosts lie 15th in the league table, but a whopping 20 points above the bottom two.
The final team to hold a League Two automatic promotion spot is Plymouth Argyle, who have only managed to pick up one point in their last three matches.
The Pilgrims, who have lost to Barnet (1-0) and Accrington Stanley (2-1) recently, risk losing their place in the top three should they slip-up again when they entertain Luton Town at Home Park.
The Hatters had won four games on the bounce, but that encouraging streak came to an end following last weekend’s 1-0 home defeat to the hands of Crawley Town.
Looking to capitalise if Plymouth stumble once more are the likes of Bristol Rovers and Accrington, who play Newport County and Dagenham respectively on Saturday.
The Pirates are just three points outside the automatic promotion spots after putting together a four-game winning run, with their encounter against the Exiles, who have risen to 17th in the standings, being the division’s early kick-off at 12:30pm.
Meanwhile the Conference bound Daggers face another enormous task to gain all three points against high-flying Accrington, despite John Coleman’s men having only one once in their last six outings.
John Still’s home side are currently nine points adrift of safety at the foot of the table, with only nine fixtures remaining of the 2015-16 campaign.
Just a place above them are York City, who travel to play-off contenders AFC Wimbledon.
After being rocked by the news that winger Michael Coulson will join Scottish outfit St Johnstone as of next season on Thursday, the Minstermen could be in further trouble come Saturday evening as they already lie seven points short of survival and face a Wimbledon side who are just three points outside the top seven.
After defeating title contenders Oxford last weekend; Leyton Orient could climb up into the play-off spots this evening if they manage to record back-to-back league wins with victory over Morecambe at Brisbane Road.
The O’s are level on points (56) with seventh-placed Wycombe Wanderers after Jobi McAnuff’s winner at the Kassam Stadium a week ago, although 18th placed Morecambe will be no pushovers after winning their last outing against Wimbledon 2-1.
In other games; play-off candidates Wycombe and Carlisle United, who are separated by just four points before kick-off, go head-to-head at Adams Park, meanwhile sixth-placed Portsmouth will be eager to get back to winning ways immediately when they visit Mansfield Town.
Despite sitting 20th in the table; Yeovil Town could seal their fifth straight league win when they welcome Cambridge United to Huish Park, whilst one place below them is Hartlepool United, who take on Crawley Town at the Checkatrade.com Stadium.
The only other game sees bottom-half duo Notts County and Exeter City play each other at Meadow Lane.