Leaders Plymouth take on struggling Dagenham & Redbridge as they look to secure their first win in three games.
Argyle succumbed 2-1 to Exeter in the Devon derby last weekend before drawing 1-1 to Leyton Orient in the week, reducing their cushion at the top to just two points.
The Green Army have the joint best away record in the league with six wins in nine attempts and they’ll look to improve upon that stat as they travel to Victoria Road.
At the other end of the table are Redbridge, whose crucial midweek 1-0 victory away to Wimbledon lifted them off the foot of the table and out of the relegation zone on goal difference.
Without a win at home so far in the league, it will be difficult for The Daggers to get anything against a side 21 places and 27 points ahead, but it will not stop boss Wayne Burnett from trying.
Northampton are one of two teams within striking distance of Plymouth as they are two points behind on 37.
Town’s troubles off the pitch look set to be gone after Kelvin Thomas’ takeover this week, but on the pitch results have been promising with three straight league wins which will be pleasing for manager Chris Wilder.
Visiting are bottom of the Football League Yeovil, who are without a league win since September 5.
With five points on their travels so far and two points from their previous seven matches, a trip to Sixfields is not the best timing for The Glovers who cannot seem to stop their slide down the divisions.
Oxford are level on points with Northampton but have a far superior goal difference, which means they are also within touching distance of the top.
Taking 10 points from their last 12, head coach Michael Appleton has got them playing well and United will want to keep the pressure on Argyle.
Welcoming The Us are Hartlepool, who want to continue distancing themselves from the drop. A rather healthy eight points separate Pools from the relegation zone, but with their midweek game against Accrington postponed due to a waterlogged pitch, some teams below have closed the gap.
A team in dire trouble are York, who were thrashed 6-0 by Portsmouth on Tuesday. The result was their fifth consecutive league defeat and they have been busy before their clash against high-flying Accrington, signing five players on loan.
The Minstermen’s new boys include midfielder Kenny McEvoy from Spurs and defender Stefan O’Connor from Arsenal, as boss Jackie McNamara looks to shake his squad up with some fresh faces.
We are served up an extra treat this weekend with the West Country derby between 10th placed Exeter and 13th placed Bristol Rovers.
City are unbeaten in three, including a win against league leaders Plymouth, and are just one point off of a coveted play-off spot.
Manager Paul Tisdale has even more reason to smile after praising 38-year-old and 2003 FA Cup finalist Matt Oakley’s return to the squad in the last two fixtures.
With two straight defeats, Rovers boss Darren Clarke is desperate for his side to improve in the final third.
The Pirates have the joint highest away day point’s return with 19 from a possible 27 and will fancy their chances of taking a share of the spoils.
Leyton Orient’s draw away to Plymouth on Tuesday meant The O’s remain in a play-off place, with only a point keeping them from falling out of the top-seven.
A win and a draw from their last two, being forced to stay in a hotel may have had the right effect on the players and staff, who had previously only recorded two wins from 12.
They take on fellow London club Wimbledon, who were defeated by Redbridge in the week. Sitting in 11th on 27 points, a win will put them level with their opponents.
Unbeaten in six but only four points from safety, Newport are two places above the drop and have yet to secure a win at home this season.
Despite a 1-1 draw against promotion pushing Oxford in the week, manager John Sheridan still believes they are in danger of going down this season.
They welcome mid-table Luton, who surrendered a 3-1 lead to lose 4-3 at home to Carlisle on Tuesday.
Town are four points off the play-offs and will surely have a desire to make a claim for one of those places as they visit Rodney Parade.
All League Two Matches:
Barnet vs Mansfield
Cambridge vs Notts County
Carlisle vs Crawley
Dag & Red vs Plymouth
Exeter vs Bristol Rovers
Hartlepool vs Oxford
Leyton Orient vs Wimbledon
Newport vs Luton
Northampton vs Yeovil
Stevenage vs Morecambe
Wycombe vs Portsmouth
York vs Accrington