Championship outfit Sheffield Wednesday’s reward for knocking out Premier League side Newcastle in the last round is a home tie, and a repeat of the 1993 final, when Arsenal visit Hillsborough.
The Owls will be hoping to extend an eight-game unbeaten spell, but will face a tough task against Arsene Wenger’s side, who will be buoyed by four wins on the bounce themselves.
Petr Cech will start in goal for the visitors, while the Owls are without the cup-tied Fernando Forestieri.
Meanwhile, another Championship side hoping to cause an upset will be Aitor Karanka’s Middlesbrough when they head to Old Trafford to face Manchester United.
The Teesiders haven’t been in the best form of late, winning only one of their last four in the league. However, after victory away at Wolves on Saturday, Boro will be hoping to become the first team to win at Old Trafford this season.
Louis van Gaal put out a strong side against Ipswich last time out and is expected to do so again as he goes in search of his first piece of silverware for the Red Devils.
Winners in 2014, Manchester City, will be hoping to add another League Cup trophy to their collection, but first they must overcome Crystal Palace at The Etihad.
Manuel Pelligrini’s men, who are at the summit of the Premier League, will be hoping for a repeat of the game between the sides earlier this season, when they ran out 1-0 winners at Selhurst Park.
Jurgen Klopp gets his first taste of an English domestic cup when the competition’s most successful side Liverpool host Bournemouth.
The German, whose first three matches have ended in draws, will be hoping to get a maiden win in charge against a team thumped 5-1 by Tottenham in the league at the weekend.
A much-changed Leicester City will make the trip to Humberside when they face Steve Bruce’s Championship high-flyers, Hull City. The Tigers who already have a Premier League scalp to their name, eliminating Swansea in the previous round.
According to some reports, Chelsea manager Jose Mourinho has two games to save his job. The first of those is a tricky away tie at fellow top-flight side, Stoke City.
The holders, who are expected to field a strong starting XI in order to find some form, will be without Nemanja Matic, who was sent off in the defeat to West Ham.
Mark Hughes will be keen to see his side bounce back from a disappointing display at home to Watford at the weekend. Captain Ryan Shawcross is in line for a return after a lengthy spell away following back surgery.
Aston Villa axed manager Tim Sherwood on Sunday, so Kevin Macdonald will take charge when they travel to St Mary’s to face Southampton.
The Villans, finalists in 2010, haven’t registered a victory since the 1-0 win over Birmingham in the last round.
Meanwhile, Saints, who are without the suspended Sadio Mane, are unbeaten in five and were the star performers in the last round, thrashing MK Dons 6-0.
It will be an all Premier League affair at Goodison Park as Everton host Norwich City.
The hosts will be without the suspended Gareth Barry and Phil Jagielka, who has been ruled out for two months with a knee injury.
Alex Neil has conceded that top flight consolidation is his aim for this season so is expected to ring the changes, meaning summer signing Youssouf Mulumbu might make an appearance after returning from a foot injury.
Sheffield Wednesday vs Arsenal
Everton vs Norwich City
Hull City vs Leicester City
Stoke City vs Chelsea
Wednesday (7:45pm unless stated)
Manchester City vs Crystal Palace
Liverpool vs Bournemouth
Southampton vs Aston Villa
Manchester United vs Middlesbrough (8pm)