The champions picked up an overdue first win of the season at West Brom last weekend and will be eyeing another three points in a re-run of the fixture that saw them seal the league title with a 1-0 win back in May.
John Terry serves his one-match suspension for his sending off at West Brom, opening the door for Gary Cahill to return to the defence alongside Kurt Zouma.
New left-back Baba Rahman is not yet match fit so is unlikely to feature, whilst Oscar and forgotten man Victor Moses are doubtful.
Pedro scored on his debut last weekend and will make his home bow, whilst on the other wing Chelsea are looking for more from Eden Hazard; last season’s PFA Player of the Year has had a slow start this time out but did get an assist at the Hawthorns.
This weekend’s match is Mourinho’s 100th home Premier League game in charge of Chelsea, and he is looking to mark the occasion by collecting a 77th Stamford Bridge victory. He has suffered defeat just once in his 99 games in the home dugout so far.
Palace, who have won two of their opening three matches, are boosted by the return of winger Yannick Bolasie, who missed last weekend’s win over Aston Villa having been granted compassionate leave following the death of his father.
Mile Jedinak picked up a hamstring injury against Shrewsbury in midweek and won’t feature this weekend, but aside from that Alan Pardew has no fresh injury concerns.
The Eagles have picked up more points on the road than any other Premier League team in 2015 so won’t be intimidated by a trip to West London, but Pardew will have to get his tactics spot on if he is to spoil Mourinho’s landmark day.
League Position: Chelsea – 10th, 4pts; Crystal Palace – 5th, 6pts
Last Meeting: Chelsea 1-0 Crystal Palace, 3rd May 2015
Key Men: Chelsea – Eden Hazard; Crystal Palace – Yohan Cabaye
Form: Chelsea – DLW; Crystal Palace – WLW
Shoot Says: Chelsea 2-1 Crystal Palace