Plymouth Argyle welcome Morecambe to Home Park, looking to maintain their four-point lead at the top.
The Pilgrims bounced back from their defeat at Oxford with a 2-1 win over Luton last time out.
Now they go in search of their sixth victory from eight home matches against the Football League’s highest scorers who sit two points outside the top-seven and have lost just once on the road all term.
If Plymouth drop points, second-placed Portsmouth will be looking to take advantage in their trip to Notts County.
Paul Cook’s side are unbeaten away from home and in their last five games, while County are six off the play-offs after putting together a three-game run without defeat.
Stevenage are perched five points above the bottom-two after their three-game unbeaten run was ended by Northampton last time out.
Now Tedddy Sheringham’s side host third-placed Oxford, whose seven-match unbeaten run was surprisingly ended by Barnet last weekend.
Northampton, Stevenage’s conquerors last weekend, travel to a rejuvenated Newport on Saturday.
Town, who have lost just one of their last nine despite off-field financial problems, face a County side 22nd but on a two-game winning streak.
Wycombe Wanderers halted a run of three straight defeats with a 1-1 draw against Carlisle last week, and the Chairboys face another tough test this time round as they play fifth-placed Mansfield.
The Stags have lost just three of their 15 matches this term and have already won five on the road – two more victories than Wanderers have at Adams Park.
Two teams in the play-off places clash in London as Leyton Orient take on Accrington Stanley.
The O’s recorded just their second win in 10 matches last time out against Morecambe, but they have lost just once at home all season.
Meanwhile, Stanley’s 3-1 victory over Dagenahm & Redbridge means John Coleman’s men have won six of their last nine in the league.
York City begin life after Russ Wilcox with a trip to Crawley.
The 51-year-old lost his job after a run of nine matches without a win and will be hoping that the change will see them get a much needed three points, with the bottom-two just three points adrift.
However, the hosts will make it tough for them having won three of their last four games.
All League Two Matches:
Cambridge vs Bristol Rovers (Fri)
Crawley vs York
Wimbledon vs Hartlepool
Barnet vs Exeter
Carlisle vs Yeovil
Leyton Orient vs Accrington
Mansfield vs Wycombe
Newport vs Northampton
Notts County vs Portsmouth
Plymouth vs Morecambe
Stevenage vs Oxford United
Dagenham & Redbridge vs Luton (Sun)