In the biggest match of the weekend, Manchester United welcome arch-rivals Liverpool to Old Trafford.
Both of these sides experienced chastening defeats in their last fixtures, with plenty of question marks being asked of each backline.
Wayne Rooney is expected to miss the clash after suffering a hamstring strain, meaning Marouane Fellaini is likely to deputise ahead of new £36 million man Anthony Martial.
David De Gea will most likely come into the side for United after signing a new four-year deal with the Red Devils, but there are expected to be no changes in defence.
Michael Carrick is making good progress with his shin injury but this fixture has come a little soon for the England man meaning Ander Herrera should retain his place.
United did the double over Liverpool last season and a repeat of last year’s 3-0 home win would be a nice response to the loss at the Liberty Stadium.
Liverpool meanwhile are becoming extremely unpredictable under manager Brendan Rodgers. An impressive performance away at Arsenal was followed by the disastrous 3-0 defeat at home to West Ham which prompted anger from some fans.
The performance of Dejan Lovren in that game can only be described as horrendous and Mamadou Sakho could be a different option for Rodgers at the back.
Philippe Coutinho will be missing through suspension but Jordan Henderson and Adam Lallana may return following injuries. Joe Allen is very doubtful, while it will be another fortnight before Daniel Sturridge makes his first appearance of the season.
Despite lots of negativity following their recent result, both sides remain only two points off second place.
League Position: Manchester United – 5th, 7pts; Liverpool – 7th, 7pts
Last Meeting: Liverpool 1-2 Manchester United, March 2015
Form: Manchester United – WWDL; Liverpool – WWDL
Key Men: Manchester United – Memphis Depay; Liverpool – Christian Benteke
Shoot Says: Manchester United 2-2 Liverpool