Manchester United and near neighbours Manchester City go head-to-head at Old Trafford in the 170th Manchester derby.
For the first time in three seasons this match feels like it is being played between two title contenders.
City are in second after Arsenal’s win on Saturday, but a win at United will see them return to the top and move five points clear of their rivals.
The Red Devils know though that if they repeat last season’s victory in this fixture that they will move up to second.
United come into this game on the back of a 1-1 draw against CSKA Moscow in Russia on Wednesday.
Louis van Gaal has bemoaned the eight-hour journey his places had to take but his side should have no problems getting up for this clash.
City also played Wednesday, as Kevin De Bruyne’s late winner sealed a vital 2-1 win over Sevilla at the Etihad, but they didn’t have to travel away from Manchester.
Despite Van Gaal’s concerns, his side will be confident after putting in their best performance of the season in their 3-0 win at Everton last Saturday.
Their visitors are also on a high having scored 11 in their previous two league matches; six against Newcastle and five versus Bournemouth.
None of the last 12 derbies have ended in a draw with City winning six of the last eight meetings, but they will recall their 4-2 defeat in April.
Goals have been a major theme in this fixture with over four being averaged a game over the last 10 meetings.
Anthony Martial will again line up alongside Wayne Rooney, who’s looking to end his poor form by adding to his record-breaking 11 derby goals.
Ashley Young is still out, and he joins Paddy McNair and long-term injury victim Luke Shaw on the sidelines.
Pellegrini has yet to confirm if Vincent Kompany will return to the starting XI, but the skipper is expected to lead his side out at Old Trafford.
Otherwise, the Chilean boss remains without David Silva, Sergio Aguero, Gael Clichy, Samir Nasri and Fabian Delph.
League Position: Manchester United – 4th (19 pts); Manchester City – 2nd (21 pts)
Last Meeting: Manchester United 4-2 Manchester City, April 2015
Key Men: Manchester United – Juan Mata; Manchester City – Kevin De Bruyne
Form: Manchester United – LWWWLW; Manchester City – WWLLWW
Shoot Says: Manchester United 2-1 Manchester City