Tottenham host Anderlecht at White hart Lane looking to make amends after their 2-1 defeat in Belgium a fortnight ago.
Spurs raced into a fourth-minute lead after Christian Eriksen profited from poor Anderlecht defending, but Mauricio Pochettino’s side let their lead slip.
After that result, both teams are currently locked on four points, with Spurs sitting in second thanks to a superior goal difference.
The North London side extended their unbeaten run in the Premier League to 10 matches on Monday with a 3-1 win over strugglers Aston Villa.
But ahead of this one, Pochettino will surely have one-eye on Sunday’s North London derby against Arsenal at the Emirates.
Anderlecht have drawn one and won two of their three matches since beating Tottenham and are on a six-match unbeaten run in all competitions.
However, they have yet to win on English soil, losing 12 and drawing one of their 13 matches in this country.
Spurs haven’t beat the Brussels side in normal time in their five previous meetings though, but they did defeat them on penalties to win the 1984 UEFA Cup.
Andros Townsend will miss Thursday’s clash after he was banished from the first-team squad for being involved in a clash with fitness coach Nathan Gardiner.
The winger was an unused substitute for Spurs’ home win over Aston Villa on Monday, and the 24-year-old England international was pictured pushing and arguing with Gardiner after the game.
As a result, Pochettino revealed that the winger would not be considered for selection.
Son Heung-min, the South Korean forward, is in contention to return after six weeks out with a foot problem, but a hamstring injury could prevent Clinton Njie from playing any part.
Nabil Bentaleb, the Algeria international, is unlikely to be risked after just returning to training after two months out with an ankle problem.
Anderlecht will be relying on Stefano Okaka to find the net if they are to have any chance of travelling back to Belgium with any more points on the board.
The Italian striker has eight goals in 16 matches this season and scored the winner against Spurs two weeks ago.
Group Position: Tottenham Hotspur – 2nd (4 points); Anderlecht – 3rd (4 points)
Last Meeting: Anderlecht 2-1 Tottenham Hotspur (October 22, 2015)
Key Men: Tottenham Hotspur – Harry Kane; Anderlecht – Stefano Okaka
Form: Tottenham Hotspur – DDDLWW; Anderlecht – DWWWDW
Shoot Says: Tottenham Hotspur 2-0 Anderlecht