Despite being winless this term, Tottenham did the double over Everton last year and are very much on top when it comes to this fixture.
The Toffees have not won at White Hart Lane since 2008 and have lost there in three of their last four seasons.
Mauricio Pochettino will be delighted to now have Heung-Min Son in his squad after the 23-year-old completed his £22 million move from Bayer Leverkusen on Friday. It remains to be seen if the South Korean will be given a start straight away, but if so Nacer Chadli could make way.
Andros Townsend is a doubt while Pochettino will be counting the days until Christian Eriksen returns from a knee injury.
Everton fielded a strong team against Barnsley in the League Cup on Wednesday and many may be tired after playing the full 120 minutes.
Brendan Galloway is expected to miss Saturday’s match with Bryan Oviedo or Ty Browning the most likely replacement.
John Stones will again play and many will be watching to see if he can improve on his below-par display against Barnsley amidst transfer rumours.
Gerard Deulofeu could well get his first start of the season after his impressive impact midweek with Tom Cleverley possibly missing out.
The Toffees signed striker Leandro Rodriguez on Friday but he won’t play any part at the Lane.
League Position: Tottenham – 16th, 2pts; Everton – 7th, 4pts
Last Meeting: Everton 0-1 Tottenham, May 2015
Form: Tottenham – LDD; Everton – DWL
Key Men: Tottenham – Harry Kane; Everton – Romelu Lukaku
Shoot says: Tottenham 2-1 Everton