Plymouth extended their lead at the top of the table to five points after beating Morecambe 2-0 at Home Park.
Two goals in the opening 12 minutes from Graham Carey and Craig Tannner sealed a sixth win from seven games for the hosts.
Portsmouth lost their unbeaten away record and slipped down to third as Notts County came from behind at Meadow Lane to win 2-1.
Pompey now haven’t won in three, while County are now four off the play-offs after extending their unbeaten run to four matches.
Oxford United are now Plymouth’s closest challengers at the top as they bounced back from their first defeat in seven matches last week to beat nine-man Stevenage 5-1.
Ryan Taylor scored twice for the U’s who saw Liam Sercombe score and miss a penalty as Teddy Sheringham’s side lost their discipline and stay just five points clear of the bottom-two.
Accrington Stanley’s impressive start to the season continued with a brilliant 1-0 win at Leyton Orient.
Josh Windass scored the only goal of the game to move Stanley up to fourth as the O’s slip to seventh.
Newport’s revival under John Sheridan continues as they came from 2-0 down to 2-2 against in-form Northampton.
County are now four points clear of the drop after picking up seven points from their last three games, while Town sit fifth.
Barnet’s fantastic home form looks like it could be a big factor this term as they saw off Exeter 2-0 at The Hive.
Martin Allen’s side have picked up 16 points from eight home matches now, while the Grecians have now won just once in their last six matches.
Luton ended a four-match winless run Sunday as they beat strugglers Dagenham & Redbridge 2-0 in London.
Luke Guttridge and Alex Lawless got the goals which see Town move to within four points of the play-offs and keep the Daggers three points from safety at the bottom.
Richard Cresswell lost his first game in caretaker charge of York City as the Minstermen went down 1-0 at Crawley.
The result keeps City in 22nd, three points above the bottom-two as Crawley move 12 clear of the drop following a second successive win.
Mansfield lost ground on the top-three as they were beaten 2-0 at home by a Wycombe side which ended their five-match winless run.
Yeovil stay in the bottom two as their winless streak stretched to eight games following a 3-2 defeat at Carlsile.
The Glovers took a 2-0 lead in the first eight minutes but left with nothing after a goal from Macaulay Gillesphey and a Michael Raynes brace.
Wimbledon won their fourth home match of the season as they extended Hartlepool’s winless run to three matches with a 2-0 victory at Kingsmeadow.
Cambridge lost for the fourth time in seven matches at home to Bristol Rovers – a result which has since seen the club end manager Richard Money’s three-year spell in charge.
The win was the Pirates’ sixth win from eight away matches and they move to within three points of the play-offs.
Player of the Week: Ryan Taylor (Oxford)
Team of the Week: Notts County
Goal of the Week: Graham Carey (Plymouth)