Reading are the lowest-ranked side to make the FA Cup quarter-finals following their 3-1 victory at home to West Bromwich Albion.
Fellow Championship side Hull City have also been drawn in the next round after they drew 0-0 away to Arsenal, setting up a replay at the KC Stadium.
Elsewhere, there were wins for Premier League sides Chelsea, Crystal Palace, West Ham United, Watford, Everton and Manchester United.
But as the competition reaches the last eight, who were the top performers over the course of the Fifth Round weekend?
Here are Shoot’s Top 5 FA Cup Fifth Round stars…
5. Wilfried Zaha (Crystal Palace)
Crystal Palace manager Alan Pardew tipped his young wing wizard to make England’s Euro 2016 squad after his impressive performance in a 1-0 victory over Spurs at White Hart Lane.
The 23-year-old was a key player defensively and tormented Mauricio Pochettino’s side’s back four all afternoon, grabbing the match-winning assist on the stroke of half-time.
Collecting the ball in the middle of the pitch, 25 yards from goal, Zaha showed good close control and strength before sliding the ball in for Martin Kelly to fire home at Michel Vorm’s near post, with the former Liverpool man scoring his first goal for the club in the process.
4. Michael Hector (Reading)
The Royals came from a goal down to beat Premier League side West Brom, with Chelsea loanee Hector scoring the second and playing an influential role in the middle of the park.
Level at 1-1, the 6ft 4in Jamaica international rose the highest at the far post to head home Oliver Norwood’s in-swinging free-kick with 20 minutes remaining.
Able to play at centre-half or in midfield, he made four tackles, gained possession 16 times and drew three fouls in an imperious display which resulted in the only ‘upset’ of the round.
3. Emmanuel Emenike (West Ham United)
Former Nigeria international Emenike scored his first goals for the club in their emphatic 5-1 victory at Blackburn Rovers.
The Fenerbahce loanee netted his first goal to put the Hammers 3-1 up, tapping in at the far post from Cheikhou Kouyate’s squared pass.
He then added his second five minutes from time, collecting Dimitri Payet’s through ball which left him one-on-one with Jason Steele, who he then rounded with a stepover before firing home.
2. Eldin Jakupovic (Hull City)
Steve Bruce’s second-choice keeper made 11 saves as a weakened Hull side escaped the Emirates Stadium with a 0-0 draw.
Having already saved well from Danny Welbeck, the one-time Switzerland international made a fantastic fingertip save to push Joel Campbell’s shot onto the post.
Jakupovic dealt with 11 corners and also denied Welbeck again and Alexis Sanchez from a free-kick as the two sides settled for a result which neither manager really wanted.
1. Dimitri Payet (West Ham United)
West Ham’s talisman was once again in fantastic form as he scored twice and grabbed an assist at Ewood Park.
Having already scored a number of free-kicks this season, once again the Frenchman was on hand to curl the ball past Jason Steele from 25 yards to put the Hammers 2-1 up at the break.
The 28-year-old then lofted a delightful through ball for Emenike to finish with five minutes remaining.
There was still time for Payet to score his second, nipping in front of one defender before beating another two and firing past Steele from just inside the area.