Tottenham (H) – March 2
Currently seventh and just one point behind Manchester United in the Europa League spot in fifth, West Ham know that picking up points from the sides above them could prove crucial to their finishing position.
With Spurs serious title contenders, the Hammers would love to get one over their London rivals in the final match between the two at the Boleyn Ground.
Chelsea (A) – March 19
After a disastrous first half of the campaign, the Blues have begun to climb the table in recent weeks as they look to salvage a spot in Europe next term.
Just seven points behind the Hammers, Slaven Bilic will know that avoiding defeat at Stamford Bridge could be vital to their hopes of bringing European football to the Olympic Stadium.
Man United (H) – April 23
Currently just one point behind Manchester United in fifth, this could be the big one for the Hammers if they can stay in contention until the end of April.
With the Red Devils continuing to stutter in the league, a win for West Ham could prove vital in the race for European football.