Wednesday night’s London derby in East London is crucial for both sides, with West Ham harbouring outside hopes of a top-four finish and Tottenham chasing the Premier League title.
The Irons have lost just twice in their last 10 outings, and have not lost at home in the league since August – a run stretching over 13 matches.
That streak continued last time out, after Michail Antonio’s first-half strike earned his team a 1-0 victory over struggling Sunderland, moving the Hammers up to sixth in the table. The winger has scored in four of his last five appearances at the Boleyn Ground.
Slaven Bilic will be keen to bring European football to the Olympic Stadium next term, and three points would extend their lead over the chasing pack, which includes Southampton and Chelsea.
Meanwhile, Spurs are having an excellent season under Mauricio Pochettino, and are just three points behind table-topping Leicester City with a game in-hand – the North Londoners have lost just three games this term.
The Argentine’s young side have been defeated once in their last 10 matches, winning eight of those – including their last six since a 1-0 home loss against the Foxes in January.
Tottenham have lost just once on the road this season, and that came on the opening day when Manchester United beat them by virtue of a Kyle Walker own goal, while they won 2-1 at title rivals Manchester City in their last away trip in the top flight.
In the reverse fixture, Spurs thrashed the Hammers 4-1 at the Lane, with Harry Kane amongst the goalscorers with a brace.
Diafra Sakho could be involved for the hosts after recovering from a thigh strain, but Sam Byram is suspended after picking up 10 yellow cards this season.
Enner Valencia is ruled out, as are Winston Reid, James Tomkins and Joey O’Brien.
Spurs captain Jan Vertonghen is ruled out until April, meaning Kevin Wimmer will continue to partner Toby Alderweireld in the centre of defence.
Dele Alli faces a late fitness test, although Tom Carroll could take his place if he does not pass it having recovered from an Achilles injury himself.
Mousa Dembele is 50-50 to feature, but is more likely to return on the weekend against rivals Arsenal.
League Positions: West Ham – 6th (43 pts); Tottenham – 2nd (54 pts)
Previous Meeting: Tottenham 4-1 West Ham (November 22, 2015)
League Form: Tottenham – WWWWWW; West Ham – WLWLDW
Key Men: West Ham – Dimitri Payet; Tottenham – Harry Kane
Shoot Says: West Ham 2-2 Tottenham