Mauricio Pochettino will be hoping his Tottenham side can build on Saturday’s surprising 4-1 win over Manchester City by claiming another scalp in the shape of AS Monaco.
The Premier League side ate on a good run of form having won four of their five matches in September, including a 3-1 win over Qarabag in the first game in this tournament.
Their opponents, who drew 1-1 at Anderlecht in their opener, have made a poor start to their domestic campaign, with the club currently lying ninth.
However, Spurs will be aware of their opponent’s quality after they knocked their North London rivals Arsenal out of the Champions League to advance to the quarter-finals of that tournament last season.
Leonardo Jardim’s side appear to be Tottenham’s toughest group stage fixture on paper so a win at the Stade Louis II would go a long way to seeing who will probably come out on top come the end of this phase.
This is the first time Tottenham and Monaco will meet in a competitive fixture, as these sides have only met once in a pre-season friendly before.
A Spurs side led by Andre Villas-Boas lost 5-2 to a Claudio Ranieri managed Monaco in August 2013.
South Korea international Heung-Min Son is the only fresh injury concern for Pochettino.
Son, who scored two goals in the win over Qarabag, has impressed since joining in the summer.
The former Bayer Leverkusen forward picked up a muscle injury in his foot in the victory over Manchester City and could be sidelined for a few weeks.
Ryan Mason remains out after picking up an injury in scoring the winner against Sunderland last month, while Nabil Bentaleb, Mousa Dembele and Alex Pritchard have not travelled to the Principality due to injury.
Monaco’s main injury doubt is Joao Moutinho. The Portuguese international midfielder has made only three Ligue 1 appearances this term and is likely to miss out.
Stephen El Shaarawy, who joined Monaco on a season-long loan from AC Milan in the summer, is likely to lead the line for the hosts.
Group Position: Monaco – 3rd, 1 pt; Tottenham Hotspur – 1st, 3 pts
Last Meeting: Monaco 5-2 Tottenham Hotspur, August 2013 (friendly)
Key Men: Monaco – Stephen El Shaarawy; Tottenham Hotspur – Harry Kane
Form: Monaco – WDLWD; Tottenham Hotspur – WWWLW
Shoot Says: Monaco 2-1 Tottenham Hotspur