Tottenham host AS Monaco knowing a point will see them finish top of Group J.
Spurs, who have already qualified for the last-32, have won three of their five Europa League fixtures, with their only defeat coming in Anderlecht.
Monaco need a win at White Hart Lane if they are to progress to the knockout stage of the competition, and also need Qarabag to get a result against Anderlecht in Belgium.
But Mauricio Pochettino’s side are in great form this term, having lost just three times in 21 competitive matches, with just one of those (League Cup defeat to Arsenal) coming at home.
Their Ligue 1 visitors are also in decent form of their own though, having drawn both their previous away Europa League matches 1-1 and tasting defeat on just two occasions from their previous 15 matches in all competitions.
October’s reverse fixture ended in a 1-1 draw in the Principality; Stephan El Shaarawy grabbing a late equaliser after Erik Lamela had given Spurs a first half lead.
Harry Kane is expected to be rested for the clash, while Nabil Bentaleb and Nacer Chadli could come into the starting line-up having both recovered from ankle injuries.
Ryan Mason and Alex Pritchard will miss out with ankle injuries, while Mousa Dembele is also sidelined due to illness.
Monaco will be without Fabio Coentrao due to a thigh injury, while Joao Moutinho, Guido Carrillo, Ivan Knight, Adam Traore, Andrea Raggi and Loic Badiashile are also missing.
Group Position: Tottenham Hotspur – 1st (10 pts); AS Monaco – 3rd (6 pts)
Last Meeting: AS Monaco 1-1 Tottenham Hotspur, October 1, 2015
Key Men: Tottenham Hotspur – Christian Eriksen; AS Monaco – Stephan El Shaarawy
Form (all competitions): Tottenham Hotspur – WDWWDD; AS Monaco – LWLDDW
Shoot Says: Tottenham Hotspur 2-1 AS Monaco